The series begins with sheriff's deputy Rick Grimes waking up from a coma in an abandoned and badly damaged hospital. Leaving the hospital, Rick discovers a post-apocalyptic world overrun with zombies
(or "walkers", as they are often referred to in-show). Rick also
discovers his wife and son are missing. Acting on a rumor from a fellow
survivor, he arms himself and begins a perilous journey to Atlanta, Georgia, where the CDC
is said to have set up a quarantined safe-zone in the city. Upon
reaching Atlanta, he soon discovers the city has instead been overrun by
the walkers.
A few miles outside the city, Rick's wife Lori and son Carl have been hiding from the walkers with Shane Walsh,
Rick's partner and best friend, who has fallen in love with Lori. They
have established a camp with a small group of fellow survivors. After
being rescued from Atlanta by members of the group and reunited with
Lori and Carl, Rick assumes command with Shane. A band of walkers
eventually attacks the camp and kills several people. The remainder flee
to seek aid from the CDC.
In the CDC, all but one staff member, Dr. Edwin Jenner, have either
fled or committed suicide. Dr. Jenner explains that his research into
the infection has not yielded a cure, and he has not been in contact
with anyone for a long while. Lack of fuel for the emergency generators
soon initiates the building's safety protocols, which will trigger an
explosion designed to destroy the facility and prevent the escape of
deadly diseases. Jenner and Jacqui, a member of Rick's group, decide to
stay and end their struggle. Dr. Jenner whispers something into Rick's
ear, and the group escapes just as the CDC is incinerated in the
explosion.
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